LunaGel™ Ultrapure GelMA – Photocrosslinkable Extracellular Matrix

LunaGel™ Ultrapure GelMA is a highly purified, photocrosslinkable extracellular matrix (ECM) based on Rousselot X-Pure® GelMA. Ultrapure GelMA comes with ultra-low endotoxin levels (<10 EU/g), making it ideal for macrophage studies, immuno-oncology models, and translational research where immune activation must be tightly controlled.

Product Overview

Endotoxins, particularly lipopolysaccharides (LPS), can trigger inflammatory responses in immune cells, disrupting their interactions with other cell types and compromising the reliability of therapeutic testing in 3D cell culture models. This is especially critical in macrophage studies, immuno-oncology models, and translational research, where immune activation must be tightly controlled.

LunaGel™ Ultrapure GelMA solves this challenge with ultra-low endotoxin levels (<10 EU/g), ensuring a clean, immune-compatible environment for sensitive applications. Like other LunaGel™ formulations, it is highly tunable, allowing researchers to precisely control stiffness to mimic both healthy and diseased tissue microenvironments, enhancing the relevance and reproducibility of immune-cell studies.

Features

✔ Ready-to-Use Format

✔ Precise Mechanical Control – Photocrosslinking technology tunable stiffness for optimized 3D cell culture conditions.

✔ High Bioactivity – Supports cell attachment, proliferation, and proteolytic degradation, promoting physiologically relevant cell behaviour.

✔ Optically Transparent for Imaging

LunaGel™ forms optically clear hydrogels that remain stable at room temperature, ensuring seamless integration with standard imaging systems and bioassays.

✔ Reliable & Reproducible ECM for 3D Cell Culture

The highly purified gelatin-based LunaGel™ ECM supports the growth and differentiation of viable cells, organoids, and spheroids, providing a consistent and biologically relevant platform for disease modelling, drug screening, and tissue engineering.

Kit Contents

Each kit provides Everything you need for precise, tunable 3D cell culture:

Low Stiffness Kits:

✔ 5 mL LunaGel™ ECM (2x solution, sterile)

✔ 5 vials of freeze-dried photoinitiator (sterile)

High Stiffness Kits:

✔ 5 mL LunaGel™ ECM (1.5x solution, sterile)

✔ 5 vials of freeze-dried photoinitiator (sterile)

How LunaGel™ Photocrosslinkable Extracellular Matrix​ Works

LunaGel™ is a sterile, ready-to-use ECM solution supplied with a freeze-dried photoinitiator. It is available in two formulations:

Low Stiffness Kit: 0 – 6.5 kPa

High Stiffness Kit: 0 – 25 kPa

Simple 3-Step Process:

1️) Prepare – Reconstitute the photoinitiator in PBS and mix with LunaGel™ ECM and cells.

2️) Crosslink – Use the LunaCrosslinker™ to photocrosslink the solution, forming a stable 3D hydrogel.

3️) Customize Stiffness – Adjust light exposure time to precisely control mechanical properties.

Simply add your preferred culture media, and you’re ready to culture in 3D!

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